Search on: MUTL PROTEIN HOMOLOG 1 
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Descriptor English:   MutL Protein Homolog 1 
Descriptor Spanish:   Homólogo 1 de la Proteína MutL 
Descriptor Portuguese:   Proteína 1 Homóloga a MutL 
Synonyms English:   COCA2 Protein
Colon Cancer, Nonpolyposis Type 2 Protein
MLH1 Protein
MutL Homolog 1  
Tree Number:   D08.811.074.766.500
D08.811.277.040.025.215.500
D12.776.260.540.500
Definition English:   Eukaryotic homolog of the bacterial MutL DNA MISMATCH REPAIR protein. It heterodimerizes with MISMATCH REPAIR ENDONUCLEASE PMS2 to form MutL alpha, which is recruited to DNA mismatch sites by the MUTS DNA MISMATCH-BINDING PROTEIN. Mutations in the human MLH1 gene are associated with COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS. 
History Note English:   2017 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   56467 
Unique Identifier:   D000070957 

Occurrence in VHL: 		 

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